Homogenization and Characterization of Cannabidiol(CBD) Isolates

Source: https://thecannabisscientist.com/app-notes/homogenization-and-characterization-of-cannabidiol-cbd-isolates

Background

Solid isolates of CBD may be created as a non-homogenous “cake” of material, or as a mixture of loosely associated granules comprising a wide particle size distribution. Creating material suitable for consumption or subsequent formulation in other products typically requires particle size reduction and/or homogenization. Confirmation of particle size distribution of a given sample may be achieved via traditional sieving methods, or by use of a particle size analyzer.

Primary considerations when selecting a milling system for CBD homogenization include:

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  Batch size (throughput requirement – kg/batch or day)

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  Minimizing losses (physical and/ or chemical)

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  Desired final particle size range

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  Ease of cleaning to prevent batch cross-contamination

Homogenization – small scale

Small-scale (<1 kg) homogenization of CBD isolate may be achieved by lowenergy ball milling, or by automated mortar and pestle. Batches exceeding 1 kg may be processed in a continuous manner by using the PULVERISETTE 14 classic line variable speed rotor mill, with Cyclone sample collector. Configured as a continuous milling system, the P14 with Cyclone allows continuous feeding of material, and active removal of material from the rotor area – typically within a fraction of a second.